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P3‐228: Impact of 18 F‐ Florbetapir PET‐CT on Clinical Diagnosis and Management of Patients with Possible Alzheimer’S Disease
Author(s) -
Raczek Malgorzata,
Dizdarevic Sabina,
Tabet Naji,
Singh Kalpana,
Abraham Rajesh,
Fowler J. Charlotte,
Ridha Basil H.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1890
Subject(s) - medicine , medical diagnosis , dementia , referral , disease , radiology , retrospective cohort study , nuclear medicine , family medicine
perfusion without prior knowledge of CSF biomarker result. The CSF biomarker status for each individual was consequently obtained, and group observations made. Results: Individuals fell into 8 distinct groups: angular gyrus only, angular gyrus projecting frontally, angular gyrus projecting posteriorly, angular gyrus projecting temporally, frontal only, temporal only, other and no hypoperfusion. Regions in the inferior parietal lobe around the angular gyrus were the most salient for AD biomarkers, with perfusion abnormality in this region having a high likelihood of positive AD biomarkers both when alone and in combination with other regions (30/36 with abnormal amyloid, 21/36 with both abnormal amyloid and tau CSF). Interestingly, CSF biomarker status did not predict the extent of regional abnormality on perfusion imaging. Patients with frontal, temporal, other and no perfusion abnormality were rarely associated with AD type CSF biomarkers (33/45 with no abnormal CSF biomarkers). Conclusions: These results validate regional SPM-based perfusion SPECT patterns and may help increase confidence of diagnostic reporting in Alzheimer’s disease and other dementias.