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P3‐217: Subjective Depressive Symptoms are Associated with Objective Memory Decline in Preclinical Alzheimer’s Disease
Author(s) -
Seo Eun Hyun,
Kim Hoowon,
Choi Kyu Yeong,
Lee Kun Ho,
Choo IL Han
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1879
Subject(s) - boston naming test , verbal fluency test , geriatric depression scale , sobel test , cognition , medicine , dementia , neuropsychology , population , clinical psychology , psychology , recall , audiology , disease , psychiatry , depressive symptoms , environmental health , self esteem , cognitive psychology
nance or retrieval of information. However, evidence for a retention or retrieval deficit remains equivocal. It is also unclear what cognitive mechanism in working memory is impaired in MCI or early AD. Methods: We enrolled forty-six subjects from our Memory Clinics and community, with 24 amnesic MCI patients and 22 normal subjects. After neurological and cognitive assessments, they performed a classic delayed match to sample task with simultaneous event-related potential (ERP) recorded. The ERP in encoding and retrieval epoch during WM were analyzed separately. The latency and amplitude of every ERP component found in the study were compared between two groups. The ERP parameters were further analyzed to explore their relationship with neuropsychological performance. Finally, the locations of maximal difference in cortex were calculated by standard low-resolution tomographic analysis during specific time range. Results: Five components were found: P1, N1, P2, N2 and P300. The amplitude of P2 and P300 was larger in normal subjects than in MCI patients only during retrieval, not encoding epoch, while the latency of them did not show statistical difference. The latency and amplitude of P1 and N1 were similar in two groups. P2 amplitude in the retrieval epoch positively correlated with memory test (auditory verbal learning test) and visual spatial score of Chinese Addenbrooke’s Cognitive Examination-Revised, while P300 amplitude correlated with ACE-R score. The activation difference in P2 time range was maximal at medial frontal gyrus and also significant at superior frontal gyrus. However, the difference in cortex activation during P300 time range did not show significance. Conclusions: The amplitude of P2 indicated deficiency in memory retrieval process, potentially due to dysfunction of central executive in WM model. Regarding the location of P2, medial frontal plays important role in memory retrieval. The findings in the present study suggested that MCI patients have retrieval deficit, probably due to central executive (attention allocation) based on medial and superior frontal gyrus. Thus, it may provide new biomarker for early detection and intervention for aMCI.