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IC‐P‐156: Scene Encoding FMRI in Subjective Cognitive Decline
Author(s) -
Risacher Shan L.,
West John D.,
McDonald Brenna C.,
Tallman Eileen F.,
Gandhi Pratik K.,
Glazier Bradley S.,
Gao Sujuan,
Brown Steven A.,
O'Neill Darren P.,
Crosbie Ryan M.,
Brosch Jared R.,
Unverzagt Frederick W.,
Apostolova Liana G.,
Farlow Martin R.,
Saykin Andy J.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.187
Subject(s) - voxel , cognitive decline , cognition , psychology , audiology , hippocampus , effects of sleep deprivation on cognitive performance , encoding (memory) , neuroscience , medicine , dementia , disease , pathology , radiology
elwise analyses revealed widespread areas of hypometabolism (in lateral frontal, temporal, and parietal lobes) that were associated with less cognitive activity, and these regions overlapped partially the meta ROIs. Hippocampal volume was not correlated with cognitive activity in any age epoch. Conclusions: Cognitive engagement in early and midlife is associated with reduced amyloid, while current cognitive engagement is associated with reduced hypometabolism. These findings are consistent with proposed effects of early/midlife cognitive engagement on neural efficiency, but suggest that late life effects reflect other factors, such as cognitive reserve or reverse causation.