Premium
P3‐201: Combination of Verbal Delayed Recall, Stroop Color‐Word, and Mri can be Utilized for the Discrimination of Amyloid Deposition Status in MCI Individuals
Author(s) -
Sohn Bo Kyung,
Kim Jee Wook,
Yi Dahyun,
Byun Min Soo,
Choe Young Min,
Choi Hyo Jung,
Baek Hyewon,
Lee Jun Ho,
Kim Hyun Jung,
Kim Shin Gyeom,
Seo Eun Hyun,
Han Ji Young,
Woo Jong Inn,
Lee Dong Young
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1863
Subject(s) - precuneus , stroop effect , pittsburgh compound b , psychology , audiology , clinical dementia rating , dementia , posterior cingulate , neuropsychology , apolipoprotein e , default mode network , medicine , pathology , cognition , neuroscience , cognitive impairment , disease
Background:TAVI is a minimally invasive method of treating severe aortic stenosis in an elderly, multi-morbid patient population with high surgical risk compared to surgical aortic valve replacement. In aging populations, cognitive deficits are predictive of functional decline, increased mortality, and poorer quality of life. We explored the effects of TAVI on cognition by assessing cognitive performance before and 6 months after TAVI. Methods:Patients with severe aortic stenosis referred to the Sunnybrook TAVI clinic were enrolled. Cognitive performance was assessed using the Montreal Cognitive Assessment (MoCA), California Verbal Memory Test-II (verbal memory), Brief Visuospatial Memory Test (visuospatial memory), Digit Symbol-Coding test and Trails Making Test A (speed of processing) and Trails Making Test B (executive function). Test scores were normalized according to patients’ age and years of education and a z score was calculated. Paired t-tests were used to compare scores before and 6 months after TAVI. Results:Of 17 TAVI patients to date (age: 8266, 52.9% female, years of education: 13.0 6 4.3), 13 had a MoCA<26 and were impaired on at least one cognitive domain (z-score -1.5). Executive function (50%) was the most prevalent domain for cognitive deficits followed by visuospatial memory impairment (40%), impaired speed of processing (37.5%) and long term verbal memory impairment (35.3%). There were no significant changes in MoCA (t(7)1⁄4 0.32, p>0.05) or domain specific cognitive performance 6 months post-surgery (all p>0.05, n1⁄410). Conclusions:These results highlight the prevalence of cognitive impairment in patients referred for TAVI and suggest that deficits may remain unchanged postsurgery. While these preliminary results are reassuring, given the impact of even mild levels of cognitive impairment on quality of life, these findings support the need to screen for these risk factors in TAVI patients to inform future management and treatment strategies with the potential to improve patient care in this elderly population.