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P3‐187: Neuronally‐Derived Exosomal Proteins Can Predict Brain Amyloidosis
Author(s) -
Apostolova Liana G.,
Goukasian Naira,
Gylys Karen H.,
Cole Greg M.,
Teng Edmond,
Bredesen Dale E.,
Goetzl Edward J.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1847
Subject(s) - neurogranin , dementia , cathepsin d , frontotemporal lobar degeneration , amyloidosis , medicine , biomarker , pathology , oncology , endocrinology , neuroscience , psychology , chemistry , frontotemporal dementia , biochemistry , disease , protein kinase c , enzyme
cortisol who reported any alcohol consumption (p<0.0001, Synergy Index (SI): 11.6 (95%CI: 6.4-16.9)). Reducing the sample to only those who consistently consumed wine (N1⁄4293) compared with those reporting no alcohol consumption (N1⁄4224), we saw the effect increase, with those with high cortisol who reported no alcohol consumption 9.4 times more likely to develop AD compared with those with low cortisol who reported any alcohol consumption (p<0.0001, SI: 9.5 (2.9-15.9)). Conclusions: These findings demonstrate the benefit of regular moderate consumption of alcohol to combat the increased risk of AD due to the stress hormone cortisol.