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IC‐P‐153: Thinner Cortical Thickness in Patients With Subjective Cognitive Decline is Related to Poor Memory Performance and Faster Decline of Executive Function
Author(s) -
Verfaillie Sander C.J.,
Slot Rosalinde E.R.,
Tijms Betty M.,
Bouwman Femke H.,
Benedictus Marije,
Overbeek Jose,
Koene Teddy,
Vrenken Hugo,
Scheltens Philip,
Barkhof Frederik,
van der Flier Wiesje M.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.184
Subject(s) - dementia , cognition , neuropsychology , effects of sleep deprivation on cognitive performance , psychology , cortex (anatomy) , cognitive decline , audiology , working memory , cohort , temporal cortex , posterior parietal cortex , executive functions , memory clinic , medicine , neuroscience , cognitive impairment , disease
ject. Clearly, AD subjects have an “older” hippocampal age than MCI, and in turn than from CTRL. When interpolating the resulting fits to the x-axis (i.e. the point at which their hippocampi should be completely “normal”) we find that AD subjects in particular start departing from normality in their mid-30s. Robust fitting provides intercepts (age, SD) as follows: NC: 53 (6.0) years old; MCI 43.3 (7.4) y.o.; and AD 31.7 (20.6) y.o. Conclusions: While this technique requires further validation across a larger and bigger cohort, it is indicative of a departure from normality in AD patients in very early adulthood. IC-P-153 THINNER CORTICALTHICKNESS IN PATIENTS WITH SUBJECTIVE COGNITIVE DECLINE IS RELATED TO POOR MEMORY PERFORMANCE AND FASTER DECLINE OF EXECUTIVE FUNCTION Sander C. J. Verfaillie, Rosalinde E. R. Slot, Betty M. Tijms, Femke H. Bouwman, Marije Benedictus, Jose Overbeek, Teddy Koene, Hugo Vrenken, Philip Scheltens, Frederik Barkhof, Wiesje M. van der Flier, Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands; 2 Neuroscience Campus Amsterdam, Amsterdam, Netherlands; 3 VU University Medical Center, Amsterdam, Netherlands; Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands; 5 Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, Netherlands; 6 Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands; Alzheimer Center and Neurology Department, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands; 8 Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands. Contact e-mail: s.verfaillie@vumc.nl