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P3‐115: Neuroinflammation Correlates with Hippocampus Atrophy in Alzheimer’s Disease
Author(s) -
Saresella Marina,
Baglio Francesca,
Cabinio Monica,
Piancone Federica,
La Rosa Francesca,
Marventano Ivana,
Calabrese Elena,
Nemni Raffaello,
Clerici Mario
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1773
Subject(s) - neuroinflammation , microglia , atrophy , proinflammatory cytokine , hippocampus , pathology , medicine , amyloid (mycology) , immune system , immunology , inflammation
with chronological age, sex, or total Ab plaque volume, NFT density, and tau NP density. However, an increase in overall Ab vasculature volume was associated with a significant increase in total number of intermediate and amoeboid-shaped microglia in the hippocampus. Additionally, an increase in total pretangle density correlated with a significant increase in activated microglia density in neocortical regions. Changes in activated microglia morphology alsowere associated with higher levels of pretangle pathology. Specifically, the ratio of total ramified microglia/total activated microglia and the ratio of hippocampal ramified microglia/hippocampal activated microglia decreased as pretangle density increased. Conclusions:Similar to humans, elderly chimpanzees with AD-like pathology exhibit changes in microglia density and morphology.