P3‐115: Neuroinflammation Correlates with Hippocampus Atrophy in Alzheimer’s Disease | Zendy

Saresella Marina | Zendy; Baglio Francesca | Zendy; Cabinio Monica | Zendy; Piancone Federica | Zendy; La Rosa Francesca | Zendy; Marventano Ivana | Zendy; Calabrese Elena | Zendy; Nemni Raffaello | Zendy; Clerici Mario | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

P3‐115: Neuroinflammation Correlates with Hippocampus Atrophy in Alzheimer’s Disease

Author(s) -

Saresella Marina,

Baglio Francesca,

Cabinio Monica,

Piancone Federica,

La Rosa Francesca,

Marventano Ivana,

Calabrese Elena,

Nemni Raffaello,

Clerici Mario

Publication year - 2016

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2016.06.1773

Subject(s) - neuroinflammation , hippocampus , atrophy , neuroscience , disease , medicine , psychology , pathology

with chronological age, sex, or total Ab plaque volume, NFT density, and tau NP density. However, an increase in overall Ab vasculature volume was associated with a significant increase in total number of intermediate and amoeboid-shaped microglia in the hippocampus. Additionally, an increase in total pretangle density correlated with a significant increase in activated microglia density in neocortical regions. Changes in activated microglia morphology alsowere associated with higher levels of pretangle pathology. Specifically, the ratio of total ramified microglia/total activated microglia and the ratio of hippocampal ramified microglia/hippocampal activated microglia decreased as pretangle density increased. Conclusions:Similar to humans, elderly chimpanzees with AD-like pathology exhibit changes in microglia density and morphology.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research