Premium
IC‐P‐147: Atrophy Patterns Predicting Cognitive Decline in Non‐Demented Subjects are Independent of Amyloid Pathology
Author(s) -
Kate Mara ten,
Visser Pieter Jelle,
van der Flier Wiesje M.,
Scheltens Philip,
Barkhof Frederik,
Tijms Betty M.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.177
Subject(s) - dementia , atrophy , cognitive decline , biomarker , medicine , cohort , proportional hazards model , amyloid (mycology) , oncology , prospective cohort study , voxel , alzheimer's disease , cohort study , pathology , psychology , clinical dementia rating , disease , radiology , biology , biochemistry
compared to volume. Combining MRI and CSF was generally beneficial. Conclusions: MRI hippocampal texture is a promising biomarker for trial enrichment alongside the qualified hippocampal volume. Combining MRI and CSF was beneficial, especially when a low number of subjects was required. References: [1] Hill DL, et al. (2014) Coalition Against Major Diseases/European Medicines Agency biomarker qualification of hippocampal volume for enrichment of clinical trials in predementia stages of Alzheimer’s disease. Alzheimer’s & Dementia. [2] Sørensen L, et al. (2015) Early detection of Alzheimer’s disease using MRI hippocampal texture. Human BrainMapping. [3]Wyman BT, et al. (2013) Standardization of analysis sets for reporting results from ADNI MRI data. Alzheimer’s & Dementia. [4] Shaw LM, et al. (2009) Cerebrospinal fluid biomarker signature in Alzheimer’s disease neuroimaging initiative subjects. Annals of Neurology. IC-P-147 ATROPHY PATTERNS PREDICTING COGNITIVE DECLINE IN NON-DEMENTED SUBJECTS ARE INDEPENDENT OFAMYLOID PATHOLOGY Mara ten Kate, Pieter Jelle Visser, Wiesje M. van der Flier, Philip Scheltens, Frederik Barkhof, Betty M. Tijms, Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands; VU University Medical Center, Amsterdam, Netherlands; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands; 4 Alzheimer Center and Neurology Department, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands; Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands. Contact e-mail: m.tenkate1@ vumc.nl