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P3‐110: Deciphering the Role of Neuroinflammation in the Early Events of Alzheimer's Disease
Author(s) -
Keene Joshua,
Granett Britanny Alexis,
Crombez Emily Michelle,
Marchalant Yannick
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1768
Subject(s) - neuroinflammation , neurogenesis , inflammation , neurodegeneration , neuroscience , amyloid beta , immune system , disease , alzheimer's disease , biology , medicine , immunology , pathology
Background:Chrysin is a naturally occurring flavonoid may be extracted from honey and propolis. Chrysin has been reported to possess multiple biological activities including anti-inflammatory and antioxidant properties. The present study aimed to explore the role of chrysin in the management of memory deficit in mice. Methods: Swiss albino mice of either sex aged 6-8 weeks and weight 25-30 g were used. The experimental protocol was duly approved by the institutional animal ethics committee. Chrysin was administered in two doses (30 and 60 mg/kg; po) to mice for 28 successive days. Memory impairment was induced by two methods: (i) Lipopolysaccharide (LPS; 1 mg/kg; i.p.) induced amnesia; (ii) alprazolam (Alp; 0.5 mg/kg; i.p.) induced amnesia. Elevated plus maze and morris water maze tests were used to evaluate memory. After behavioural evaluation, the animals were sacrificed to estimate brain TBARS, AChE activity, GSH, Nitrite, SOD activity and catalase activity. Results:Administration of chrysin for 28 days daily prevented the LPS and Alp induced enhancement of transfer latency of mice in elevated plus maze test and reduced the escape latency on 4 day and increased the time spent in target quadrant on 5 day of morris water maze test as compared to control group animals. Furthermore, decrease in brain TBARS, nitrite levels as well as AChE activity and increase in GSH, SOD and catalase activity in chrysin treated group. Conclusions: Chrysin may prove to be useful remedy for the management of memory owing to its possible neuroprotective and antioxidant properties.