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P3‐098: TAU‐Spliceosome Interactions in Drosophila Models of Alzheimer's Disease
Author(s) -
Hsieh Yi-Chen,
Guo Caiwei,
Zhao Michelle,
Li Yarong,
Shulman Joshua M.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1757
Subject(s) - tauopathy , neurodegeneration , rna splicing , biology , spliceosome , alternative splicing , gene knockdown , intron , transgene , tau protein , microbiology and biotechnology , genetics , gene , rna , messenger rna , alzheimer's disease , pathology , medicine , disease
novel SNVs in ABCA7 (p-value1⁄4 2.6310) and EFTUD1 (p-value 1⁄4 4.9310), and a novel SNV downstream of BIN1 (p-value 1⁄4 5.4310). Conclusions: Conditional and joint analyses of IGAP Stage I data identified three novel loci, two in previously identified genes and one in a gene not previously identified as being associated with LOAD risk. Replication results with IGAP Stage II data were consistent with the initial findings.