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IC‐P‐139: Critical Analysis of Biomarker Cutoffs in Alzheimer Disease
Author(s) -
Gordon Brian Andrew,
Xiong Chengjie,
Holtzman David M.,
Fagan Anne M.,
Morris John C.,
Benzinger Tammie LS.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.169
Subject(s) - biomarker , cutoff , receiver operating characteristic , abnormality , outlier , population , neuroimaging , imaging biomarker , medicine , cohort , statistics , mathematics , magnetic resonance imaging , radiology , biology , psychiatry , physics , biochemistry , environmental health , quantum mechanics
cognitive performance, although total RBANS score declines with elevated P-tau (p1⁄40.013, Fig. 4). Conclusions:Our results suggest that in cognitively normal elderly at risk of AD, individuals with both high P-tau and low Ab1-42 levels already present associations between CSFmeasurements and brain integrity or subjective cognitive assessment. Ab1-42 and P-tau CSF markers, when used conjointly, might therefore be valuable markers to identify candidates for preventive trials. IC-P-139 CRITICAL ANALYSIS OF BIOMARKER CUTOFFS IN ALZHEIMER DISEASE Brian Andrew Gordon, Chengjie Xiong, David M. Holtzman, Anne M. Fagan, John C. Morris, Tammie LS. Benzinger, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer’s Disease Research Center, St. Louis, MO, USA; 3 Washington University School of Medicine, St. Louis, MO, USA; 4 Hope Center for Neurological Disorders, St. Louis, MO, USA. Contact e-mail: bagordon@wustl.edu