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P3‐014: Effect of Food on the Pharmacokinetics Of RVT‐101 in Healthy Adult Subjects
Author(s) -
Piscitelli Stephen C.,
Jones Lori,
Johnson Brendan,
Lombardo Ilise,
Friedhoff Lawrence
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1671
Subject(s) - pharmacokinetics , medicine , meal , adverse effect , crossover study , dosing , calorie , pharmacology , anesthesia , alternative medicine , pathology , placebo
activates eNOS, causing production of nitric oxide (NO), which then triggers transcription of genes involved inmitochondrial biogenesis (3). Thiazolidinediones, e.g., pioglitazone, induce mitochondrial biogenesis by increasing expression of PPAR-1a-coactivator, the principle regulator of mitochondrial biogenesis. (4). Treatment using concurrent combinations having different targets is more effective than sequentially using single agents. A clinical trial would test the hypothesis that a combination of lithium, erythropoietin, and pioglitazone, might impede the progression of MCI to AD, or of early to more advanced AD. Conclusions:Dysfunctional mitochondria underlie AD and may be disposed, by combining lithium, erythropoietin, and pioglitazone to enhance mitophagy, which then stimulates production of new organelles by enhancing mitochondrial biogenesis. 1. Nixon, J Cell Sci 2007;120:4081-4091. 2. Sarkar, J Cell Biol 2011;101:514-519. 3. Burger, Cardiovasc Res 2006;72:51-59. 4. Gosh, Mol Pharmacol 2007;71:1695-1702.