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P3‐003: Mexican Cross‐Cultural Adaptation/Validation of the ‘Behavioral Disexecutive Syndrome Inventory’
Author(s) -
Flores-Vazquez Juan Francisco,
Sosa-Ortiz Ana Luisa
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1660
Subject(s) - adaptation (eye) , cross cultural , equivalence (formal languages) , psychology , quality (philosophy) , computer science , applied psychology , sociology , mathematics , epistemology , neuroscience , anthropology , philosophy , discrete mathematics
Background: Conventional drug treatments of Alzheimer’s disease(AD) are ineffective because the therapeutic drugs often have low bioavailability, poor solubility, limited penetration across the blood-brain barrier(BBB). AD is a multi-factorial disease with several pathogenic mechanisms and pathways, therefore multifunctional nanotechnologic treatment methods may be needed to access the many molecular targets in AD.Methods:We have studies the effect of dendrimer’s on the process of brain amyloid formation based on two model peptides derived from the ABeta peptides. Results: We have found that these new polymers have a modulating effect on the process of fibre formation. Depending on their concentration, dendrimers may accelerate or retards the formation of amiloide fibres. This means they are a potentially powerful tool in the design of strategies to manage in vivo amyloid formation. Conclusions: Given their anti-ABeta amyloid properties and their crossing BBB, dendrimers can be potential new agent for early diagnosis and treatment of AD.