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P2‐421: Indicators of Cognitive Reserve Moderate the Adverse Relationship Between Poor Diet Quality and Cognitive Decline in Independent Older Adults: The Nuage Study
Author(s) -
Parrott Matthew D.,
Fiocco Alexandra J.,
Carmichael Pierre-Hugues,
Anderson Nicole D.,
Laurin Danielle,
Greenwood Carol E.,
Ferland Guylaine,
Shatenstein Bryna,
Gaudreau Pierrette,
Payette Hélène,
Belleville Sylvie,
Morais José A.,
Kergoat Marie-Jeanne
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1633
Subject(s) - cognition , gerontology , cognitive decline , cognitive test , effects of sleep deprivation on cognitive performance , demography , logistic regression , medicine , psychology , western diet , environmental health , obesity , psychiatry , dementia , disease , sociology
in Hualien county, Taiwan during 2014-2015 and collected serum markers of vascular risks including fasting glucose, glycated hemoglobin (HbA1c), insulin and homocysteine. Memory function was tested by Rey complex figure recall and California verbal learning tests; executive function was assessed by color trails, design fluency condition and color-word interference tests. All participants underwent 3T MRI scan protocol, and brain aging was indexed by regional cortical and subcortical gray matter volumes measured by Freesurfer software. The influence of glycemic states on frontal and subcortical gray matter volumes and cognitive performances were analyzed using linear regressions controlling for age and sex. Results: A total of 40 volunteers were recruited with mean age at 66.7 years (SD1⁄4 5.1), female predominance (68%) and mini-mental state examination score of 26 or above. Higher HbA1c was associated with smaller medial temporal lobe (MTL) volumes, mainly right parahippocampus and left hippocampus. Higher fasting glucose was associated with smaller MTL and R lateral orbitofrontal cortex, but larger R frontal poles. No associations with brain volumes were found for insulin and homocysteine levels. In addition, higher blood glucose levels were associated with poorer performance in Rey complex figure immediate and delayed recall, with HbA1c further associated with slower color trails performance. Conclusions: Higher blood glucose levels are associated with poorer gray matter structural health in frontal cortex and MTL as well as poorer memory and executive function.