P2‐420: Glycemic States Modulate Frontal and Medial Temporal Gray Matter Volumes in a Senior Volunteer Cohort: A Pilot Study

tudinal study. MCI was determined by ageand education-adjusted objective cognitive impairment (at least 1.5 standard deviations below the reference threshold) using computerized comprehensive cognitive measures including memory, attention/executive function, and processing speed. Depressive symptoms were measured using the 15-item Geriatric Depression Scale (GDS) and defined by a GDS score of 6 or more. Developing dementia and progression from MCI to dementia were the main outcome measures. Results: During the 24-month follow-up period, 65 participants (1.8%) developed dementia. Baseline MCI was significantly associated with an increased risk of incident dementia (hazard ratio [HR], 2.8; 95% confidence interval [CI], 1.6–5.0) but depressive symptoms were not (1.9; 0.9–4.1) after adjusting for age, sex, education, prescribed medications, walking speed, mini-mental state examination. Participants with comorbid MCI and depressive symptoms at baseline had a higher risk of developing dementia (HR, 4.2; 1.9–9.5). Conclusions:We found that MCI and depressive symptoms related to increased risk for incident dementia independently among non-demented community-dwelling elderly adults. We also found that the combined status of MCI and depressive symptoms showed a significantly greater impact on dementia development, with more than a four-fold greater risk compared to those without MCI and depressive symptoms. Comorbid MCI and depressive symptoms have a significantly greater impact on dementia development among communitydwelling older adults.