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P2‐361: A Correlational Analysis of IN VITRO BACE1 Inhibitory Activity with IN VIVO PK/PD Relationship in Cerebrospinal Fluid of Dog
Author(s) -
Yang Zhixiang
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1572
Subject(s) - in vivo , in vitro , ic50 , cerebrospinal fluid , pharmacology , beagle , chemistry , microbiology and biotechnology , biochemistry , biology , medicine , pathology , genetics
Background:Although most people with dementia live at home, we know relatively little about the use of home technologies for this population. This is a dire problem, given the need for effective in-home support. The purpose of this presentation is to share findings from the People and Technology at Home (PaTH) project concerning design considerations for everyday technologies; and demonstrate a systems analysis approach, called the Abstraction Hierarchy (AH), that developers may find useful. Methods: The project involved people with dementia participating in surveys, interviews and demonstrations of their own everyday home devices and appliances (n1⁄47); family caregivers participating in surveys and interviews (n1⁄47); and clinical specialists and technology developers completing in-depth surveys (n1⁄440). Technology demonstrations included devices such as portable phones, computers and microwave ovens, in which challenges experienced by users with dementia were observed and discussed. Survey topics concerned the importance of technology adoption and use characteristics, such as ‘cost’, ‘aesthetics’ and ‘self-confidence (during use)’. Results: Concerning technology acceptance, cost, learnability, selfconfidence (during use) and usability, were typically deemed ‘very important’ amongst developers, though differences between technical and clinical specialists existed. Amongst PwD and caregivers, cost was less important. During demonstrations of items such as portable phones, errors concerned the physical form of the technology (reading control pad labels), cognitive manipulations required (identifying and correctly sequencing buttons, functions and menus) and broader system functions (renewing the service contract). Based on these findings, we present a structured approach called the Abstraction Hierarchy, which allows developers to specify high-level purposes, values and constraints of a proposed system; and associated midand low-level functions and physical forms. Using the AH, we present an error analysis associated with phone use. Conclusions:With the AH, developers can capture key technology acceptance characteristics learned during ethnographic studies, such as a user’s self-confidence during device use; map and organize these and other system-wide factors; and pinpoint interdependencies between levels. Such an analysis can offer important insights, especially for developers of complex technologies for dementia care.