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IC‐P‐127: Associations Between Quantitative Tractography at 3T MRI and Cognitive Function in Alzheimer’s Disease
Author(s) -
Reginold William,
Itorralba Justine,
Luedke Angela C.,
Fernandez-Ruiz Juan,
Islam Omar,
Garcia Angeles
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.157
Subject(s) - white matter , corpus callosum , cingulum (brain) , fractional anisotropy , diffusion mri , tractography , memory span , stroop effect , psychology , boston naming test , alzheimer's disease , neuroscience , audiology , neuropsychology , medicine , cognition , pathology , magnetic resonance imaging , disease , working memory , radiology
was apparent as a single focal spot in all but 2 MCI and 2 AD patients who displayed two or more spots bilaterally. No enhancement was detected on pre-contrast FLAIR images. Leptomeningeal enhancement was associated with (non-lacunar) cerebral and/or cerebellar ischaemic stroke presence (p1⁄40.029), and marginally with white matter hyperintensity score (p1⁄40.083). The stroke location did not correspond to the site of BBB leakage. No associations between leptomeningeal enhancement and other markers of cerebrovascular damage were found. Conclusions: Post-contrast leptomeningeal enhancement on FLAIR images is prevalent in MCI and AD and may serve as a new marker for subtle BBB leakage. This type of BBB damage may be associated with ischaemic and/or inflammatory processes and possibly relates to cortical atrophy and cognitive decline. Future longitudinal MRI studies in larger samples and with post-mortem histology are needed to reveal its role in the onset and progression of dementia.