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P2‐299: Brief Neuropsychological Screening Tests for the Detection of Alzheimer's Disease in an Early Phase: A Systematic Review
Author(s) -
De Roeck Ellen Elisa,
Paul de Deyn Peter,
Engelborghs Sebastiaan,
Dierckx Eva
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1559
Subject(s) - neuropsychology , test (biology) , cognition , psychology , neuropsychological assessment , cognitive test , neuropsychological test , psychometrics , reliability (semiconductor) , psychometric tests , disease , cognitive impairment , clinical psychology , medicine , psychiatry , pathology , paleontology , power (physics) , physics , quantum mechanics , biology
shapes of trajectories (linear vs quadratic) for the Rey Auditory Verbal Learning Task (AVLT_Total, AVLT_delay: sum of learning trials and delayed recall) and the log-transformed Trails B time to completion; men and women were characterized separately. Results:For men (n1⁄4 379), 5, 4, and 5 trajectory clusters were identified for AVLT_Total, AVLT_delay, and Trails B, respectively. For women (n1⁄4 874), 4, 4, and 5 clusters were identified for AVLT_Total, AVLT_delay, and Trails B. Trajectories for AVLT_Total and Trails B are displayed in Figures 1 and 2 for men and Figures 3 and 4 for women. Trajectories were predominantly linear and were consistently significantly worse in the weakest performing groups than at least one of the other clusters. Sample characteristics are compared across AVLT_Total clusters in Tables 1 and 2 for men and women, respectively. Conclusions: These preliminary analyses demonstrate that mixture modeling techniques allow identification of latent cognitive trajectory clusters that may differ in rates of change across clusters. These modeling strategies can be useful to identify and characterize phenotypes of both preclinical AD and resilient aging which can then help to inform prevention and early intervention efforts.