Premium
P2‐284: Lipopolysaccharide and E. COLI Proteins and DNA in Alzheimer's Disease Brains Compared to Controls
Author(s) -
Zhan Xinhua,
Stamova Boryana,
Jin Lee-Way,
DeCarli Charles,
Phinney Brett,
Sharp Frank R.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1544
Subject(s) - biology , escherichia coli , lipopolysaccharide , blot , microbiology and biotechnology , immunocytochemistry , pathology , biochemistry , immunology , endocrinology , medicine , gene
mild stress. These data are characterised by increase number of hyperchromatic neurons and increase of iNOS and eNOS expression in perikaria of pyramidal neurons, at the same time it was found reducing eNOS expression in microvascular endothelium. These changes are accompanied by more severe cognitive disorders in 24-month-old rats which may accelerate the process of aging. *This investigation was supported by grant of Volgograd State Medical University.