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P2‐149: APOE4‐Specific Imbalance in Arachidonic Acid and Docosahexaenoic Acid in Serum Phospholipids from Individuals with Preclinical MCI/AD
Author(s) -
Abdullah Laila,
Evans James,
Emmerich Tanja,
Nguyen Thinh,
Crynen Gogce,
Shackleton Ben,
Reed Jon,
Keegan Andrew P.,
Luis Cheryl,
Tai Leon,
LaDu Mary Jo,
Mullan Michael,
Crawford Fiona,
Bachmeier Corbin
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1519
Subject(s) - docosahexaenoic acid , apolipoprotein e , arachidonic acid , endocrinology , medicine , context (archaeology) , allele , biology , disease , biochemistry , fatty acid , polyunsaturated fatty acid , gene , paleontology , enzyme
variants, and it has not been reported in the world. Methods: This study reports a novel S100A9 gene mutation in 5 Malaysian patient with AD. Direct sequencing of the S100A9 gene revealed a novel mis-sense mutation at codon 99 for predicting glucine to lysine substitution (E99K). Results: Additionally, dataset sequence of 60,706 unrelated individuals were screened, which could be used in the various disease-specific and population genetic studies. Conclusions: E99K is a novel S100A9 gene mutation responsible for AD in East Asia as well as in the world.