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P2‐141: FundaciÓ ACE Healthy Brain Initiative: A Study of Cognition and Biomarkers in Individuals with Subjective Cognitive Decline
Author(s) -
Rodriguez-Gomez Octavio,
Sanabria Angela,
Perez Alba,
Ruiz Susana,
Tarragona Marina,
Sanchez Domingo,
Pavía Javier,
Campos Francisco,
Vivas Assumpta,
Chiari Marta Gómez,
Tejero Miguel Angel,
Alegret Monserrat,
Espinosa Ana,
Ortega Gemma,
Abdelnour Carla,
Hernandez Isabel,
Ruiz Agustin,
Giménez Joan,
Lomeña Francisco,
Tarraga Lluis,
Sotolongo-Grau Oscar,
Boada Mercè
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1511
Subject(s) - neuropsychology , cohort , cognitive decline , cognition , neuropsychological assessment , montreal cognitive assessment , effects of sleep deprivation on cognitive performance , medicine , psychology , memory clinic , clinical psychology , gerontology , dementia , disease , cognitive impairment , psychiatry
appropriate increase in dilation at moderate loads. Conclusions: These results suggest that pupillometry is associated with altered brain activity, inflammatory state, and cognitive performance. This provides converging evidence for LC involvement, an early site of AD pathology which may provide the neural substrate linking these measures together. Given the relatively young age of the sample, TEPD may provide a simple and useful psychophysiological biomarker for early identification of AD risk.