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IC‐P‐121: Neuronal Activity Derived from Resting State Functional MRI: A Potential Biomarker for Alzheimer Disease
Author(s) -
Kazemifar Samaneh,
Manning Kathryn,
Rajakumar Nagalingam,
Gómez Francisco A.,
Soddu Andrea,
Borrie Michael,
Me Ravi S.,
Bartha Robert
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.151
Subject(s) - resting state fmri , neuroimaging , brain activity and meditation , premovement neuronal activity , alzheimer's disease neuroimaging initiative , positron emission tomography , atrophy , neuroscience , biomarker , medicine , functional magnetic resonance imaging , hippocampus , alzheimer's disease , nuclear medicine , psychology , disease , electroencephalography , biology , biochemistry
the hippocampus reported a bilateral FA decrease and an increase in RD and MD, preferentially in the right hemisphere, of MCI+ relative to MCI-. Diffusion indices in theMCI-int group were generally intermediate between MCI+ and MCI-. Conclusions: Our results suggest that i) Ab/p-tau and Ab classifications are more sensitive than Ab/t-tau classification in detecting white matter microstructural alterations in amnestic MCI patients, ii) splenium and cingulum of the hippocampus are affected at early stages in the disease. PharmaCog is funded by the EU-FP7 for the Innovative Medicine Initiative (grant n 115009).