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P2‐113: High‐Fat Diet Affects Inflammation and Increases TREM2 Level in App Mice
Author(s) -
Fitz Nicholas F.,
Nam Kyong Nyon,
Wolfe Cody M.,
Mounier Anais,
Schug Jonathan,
Lefterov Iliya,
Koldamova Radosveta
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1483
Subject(s) - trem2 , transcriptome , inflammation , epigenome , biology , endocrinology , medicine , lipidome , h3k4me3 , phenotype , morris water navigation task , microglia , gene expression , hippocampal formation , gene , genetics , lipid metabolism , dna methylation , promoter
similarities on clinical phenotypes and nervous pathologies, many studies are focused on investigating the links between them, exploring the expression of PrPc in AD brains might help to figure out the roles of PrPc in AD and aging. The present study observed the expression of PrPc in AD and normal aging brains, trying to explain the role of PrPc in brain aging. Methods: Immunohistochemistry (IHC) staining was applied on 46 cases of brain tissues from Alzheimer’s patients and normal controls of different ages (NC11⁄4middle aged, NC21⁄4aged and NC31⁄4advanced aged). Results:PrPc was found to be positive in frontal lobe and hippocampus of AD and NC2, NC3 groups. Expression of PrPc in frontal lobe was significantly higher in AD group than in NC1 group (P<0.05), whereas in hippocampus, the expression of PrPc was significantly increased in AD brains compared to NC1 and NC2 brains (P<0.05). Furthermore, the IOD ratios of PrPc staining were increased with aging and increased in AD brains compared to all the normal brains (P<0.05). Conclusions:PrPc is elevated in AD and aged brains, which may contribute to brain aging.