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P2‐345: Verbal Associative Binding is Associated with Amyloid‐Beta Deposition in Self‐Referred Subjective Memory Complainers But not in Cognitively Normal Volunteers
Author(s) -
Snitz Beth E.,
Cohen Ann D.,
Lopez Oscar L.,
Price Julie,
Mathis Chester,
Aizenstein Howard J.,
Klunk William E.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1475
Subject(s) - prodrome , psychology , cognition , neuropsychology , neuroimaging , episodic memory , association (psychology) , semantic memory , audiology , clinical psychology , psychiatry , medicine , psychosis , psychotherapist
campal atrophy in non-demented individuals are potential markers of early-stage Alzheimers disease (AD). The aim of this study was to assess the relationship between left and right hippocampal volumes and specific SCC and to compare it to standard, routinely used memory tests. Methods: Eighty one non-demented older adults (22 with amnestic mild cognitive impairment, 7 with non amnestic mild cognitive impairment and 52 cognitively healthy older adults) underwent comprehensive neuropsychological testing, 1.5T brain MRI scans with quantitative volumetry using FreeSurfer package (version 5.3.0) to measure estimated total intracranial volume (eTIV) along with adjusted right and left hippocampal volumes, and were administered a 10-item yes/no questionnaire to evaluate SCC in the last 6 months. Spearmans correlation was used to correct for non-normal score distribution. Subjects with significant vascular changes (Fazekas score >1) and depression (>5 on 15 item Geriatric depression scale) were not included. Results: We found significant correlations of both hippocampal volumes with “Difficulties with recalling past events” (rR1⁄4.-29 and rL1⁄4-.33) and “Feeling of memory change” (rR1⁄4-.24 and rL1⁄4-.23) items, and with the total SCC score (rR1⁄4-.19 and rL1⁄4-.23). Left hippocampal volume correlated with “Worse memory in comparison to peers” (r1⁄4-.19) and “Subjective limitation in daily activities” (r1⁄4-.23) items. Auditory Verbal Learning Test learning (trials 1 to 5) and delayed recall correlated with left hippocampal volume (both rs1⁄4.19). All ps’ were <.05. We did not find any correlation between any SCC item or any memory scale and eTIV. Conclusions: Specific SCC reflect hippocampal atrophy equally well as standard memory tests in non demented older adults and should be taken into account when identifying individuals in early-stage AD.