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P2‐344: Subjective Cognitive Complaints Reflect Hippocampal Atrophy in Nondemented Older Adults as Well as Objective Memory Testing
Author(s) -
Vyhnalek Martin,
Markova Hana,
Nedelska Zuzana,
Nikolai Tomas,
Laczo Jan,
Andel Ross,
Uller Miroslav,
Sheardova Katerina,
Hort Jakob
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1474
Subject(s) - boston naming test , audiology , hippocampal formation , psychology , neuropsychology , alzheimer's disease , atrophy , cognition , depression (economics) , hippocampus , episodic memory , memory impairment , geriatric depression scale , verbal learning , medicine , neuropsychological test , dementia , psychiatry , neuroscience , disease , depressive symptoms , economics , macroeconomics
Background: Self-reported subjective cognitive decline (SCD) could represent an early sign of Alzheimer’s disease (AD). Yet, the type of cognitive complaint associated with preclinical AD needs to be refined. We aimed at identifying specific types of complaint associated with i) medical help seeking, ii) the presence of actual memory impairment among patients referring to a memory clinic. We also assessed whether specific patterns of complaints were associated with neuroimaging biomarkers. Methods: We included three groups of nondemented elder individuals (Fig1): i) Healthy Aged Subjects (HAS, n1⁄461), ii) patients from a memory clinic with SCD but normal neuropsychological assessment (SCD, n1⁄429), iii) patients with amnestic Mild Cognitive Impairment (aMCI, n1⁄473). Participants filled the Cognitive Difficulty Scale questionnaire (CDS), consisting of 39 items on a 5-point scale. They underwent cognitive assessment, structural MRI and a subgroup had Florbetapir-PET to assess Ab burden. The questionnaire was analyzed in two complementary ways. First, between-group comparisons were conducted item-by-item using non-parametric tests to identify items related to medical help seeking (HAS