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P2‐338: Memory Complaint in Adult and Elderly People in a Brazilian Urban Community
Author(s) -
Carvalho Vale Francisco Assis,
Dalpubel Daniela,
Ribeiro Estela B.,
Almeida Mariana Luciano,
Araújo Renata Bezerra,
Cominetti Marcia R.,
Caramelli Paulo,
Barbosa Maira Tonidandel,
Benze Benedito G.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1468
Subject(s) - depression (economics) , anxiety , medicine , complaint , correlation , cognitive impairment , elderly people , clinical psychology , psychiatry , psychology , cognition , demography , gerontology , geometry , mathematics , sociology , political science , law , economics , macroeconomics
subjects.Anosognosiawasassessedbycomparing responsesof patients and caregivers on an anosognosia questionnaire in 3 domains (cognitive, physical, behavioral), with higher positive scores indicating a higher level of anosognosia. MCI subjects had MOCA scores>15 and satisfiedPetersonet al, 1997criteria for a-MCIandna-MCIandLitvan et al, 2012 criteria for MCI-PD. All subjects completed a full neuropsychological evaluation and depression screening measure. Volumetric analysis (NeuroQuant ) of T1-weighted brain MRI provided detailed regional and whole brain volumes corrected for intracranial volume. Univariate ANOVA and correlational analyses were employed to identify group differences in anosognosia scores and relationships between anosognosia scores and cognitive, mood, and volumetric measures. Results:Anosognosia scores did not differ significantly between the groups. In the a-MCI group, higher anosognosia scores were associatedwith poorer encoding/storage in verbal memory (i.e., delayed recall and delayed recognition of a word list). Greater anosognosia in the na-MCI group, however, was associated with poorer retrieval from verbal memory (poor delayed recall of the word list but not recognition performance). In the a-MCI group, greater anosognosia in the cognitive domain correlated with lower total brain volume and lower right forebrain parenchymal volume. Higher depression scores were associated with lower anosognosia scores (better insight) in theMCI-PD group. Conclusions:Contrary to our hypothesis, our findings suggest that anosognosia is equally likely to occur in aMCI, na-MCI andMCI-PD patients. However, the unique associations noted in the three groups indicate that there may not be a common pathobiology for anosognosia among MCI subtypes.