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IC‐P‐116: Lateral Entorhinal Cortical Thinning Predicts Cognitive Decline in The ADNI Sample
Author(s) -
Roberts Jared M.,
Holbrook Andrew,
Tustison Nicholas,
Stone J.,
Avants Brian,
Cook Philip,
Gillen Daniel,
Yassa Michael A.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.146
Subject(s) - entorhinal cortex , neuroscience , neocortex , cognitive decline , neurodegeneration , hippocampus , cortex (anatomy) , dementia , confounding , psychology , biology , disease , medicine , pathology
MC than in NC, and increased with more progressed EYO and higher dementia rating scale (CDR) scores in the MC subjects. For the factor analysis of cortical thickness, 3 factors explained 56% of the variance. Within the MC group, we observed a significant interaction between sTREM2 x EYO onto the factor scores of predominantly frontal cortical thickness (beta1⁄4 0.11, p1⁄4 0.03). Inspection of figure 1 shows that a positive association between higher sTREM2 and cortical thickness started to emerge after the estimated symptom onset. No associations were observed in NC. Conclusions:TREM2 increases during the course of AD. However, higher TREM2 is associated with greater frontal cortical thickness during more advanced stages, potentially due to compensatory processes in the frontal lobe or due to TREM2-mediated phagocytotic and non-inflammatory immune response to apoptotic processes.