Premium
IC‐P‐115: CSF Levels of Strem2 are Associated With Greater Frontal Cortical Thickness During Advanced Disease Stages in Autosomal Dominant Alzheimer Disease
Author(s) -
Ewers Michael,
Suarez-Calvet Marc,
Araque Caballero Miguel A.,
Kleinberger Gernot,
Fagan Anne M.,
Moulder Krista L.,
Benzinger Tammie L.S.,
Haass Christian
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.145
Subject(s) - trem2 , cerebrospinal fluid , dementia , microglia , clinical dementia rating , apolipoprotein e , analysis of variance , medicine , disease , psychology , neuroscience , pathology , endocrinology , inflammation
sulting maps were smoothed using a surface kernel of 10 mm FWHM, benefiting from the surface-based analysis advantages (spatial smoothing and inter-subject registration). A two-sample t-test with age and gender as covariates were performed between typical and atypical EOAD groups and results were cluster-wise corrected for multiple comparisons (p < 0.05). Results: Bilateral patterns of hypometabolism, which tended to be symmetrical, were radically different in typical and atypical EOAD (Figure). Atypical EOAD showed significant lower glucose metabolism in bilateral temporo-parietal junctions, parietal, lateral occipital and in left precentral and lingual cortices. In contrast, typical EOAD presented greater hypometabolism in bilateral medial temporal, insula, medial orbito-frontal, cingulate and in right superior frontal and precuneus cortices. Atypical presentation had a more severe reduction of regional glucose metabolism in the association cortices, while typical presentation showed a more prominent metabolic deficit close to paralimbic area. This well explained the patterns of clinical and neuropathological findings in AD. Conclusions:A surface-based analysis has been proposed on PET hypometabolism in typical versus atypical presentation in EOAD. This work showed that these different presentations were well correlated with distinct hypometabolism profiles. Previous studies did not differentiate typical or atypical presentation in EOAD. From now on, this heterogeneity should be taken into account in longitudinal studies or therapeutic interventions.