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P2‐304: Deficits in Visual Recognition Memory: A Marker of Early Mesial Temporal Lobe Degeneration in Nondemented Outpatients from Memory Clinics?
Author(s) -
Ceccaldi Mathieu,
Bouteloup Vincent,
Mangin Jean-Francois,
Didic Mira,
Barbeau Emmanuel,
Dubois Bruno,
Ousset Pierre Jean,
Pasquier Florence,
Dartigues Jean-François,
Blanc Frederic,
Gabelle Audrey,
Salmon Pierre Krolak,
Hugon Jacques,
Ha Olivier,
Rouaud Olivier,
David Renaud,
Chene Geneviève,
Dufouil Carole
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1434
Subject(s) - entorhinal cortex , boston naming test , temporal lobe , neuropsychology , audiology , psychology , hippocampal sclerosis , memory clinic , population , visual memory , medicine , hippocampus , neuroscience , cognition , epilepsy , cognitive impairment , environmental health
tia screening. Semantic and phonemic production criteria were extensively evaluated; however, unconstrained VF has been poor investigated along aging process. Thus, this study aimed to verify if there are differences between the performance, the frequency of deficits and the diagnostic accuracy of unconstrained, phonemic and semantic VFT among healthy elders (HE), Mild Cognitive Impairment (MCI) and mild Alzheimer’s disease (AD) patients. Methods: The total sample was 94 participants: n1⁄424 AD (age: 74.9266.99, education: 6.5864.88), n1⁄440 MCI (age: 70.6867.38, education: 8.8864.95) and n1⁄430 HE (age: 68.1366.45, education: 14.2764.95). Participants were assessed using VFT (unconstrained (UVF), phonemic (PVF), and semantic (SVF)) from the Montreal Communication Evaluation Battery. MANCOVA controlling age, education, and Frequency of reading and writing, was used to evaluate the significant differences among group means. The prevalence of impairments on each task, defined by means of a Z-score -1.5, was then compared among groups using Pearson Chi-Square. ROC curves were conducted to assess diagnostic accuracy of the VFT which presented deficits among the groups. Results: HE presented better performance in all VFT than MCI and AD patients (UVF: HE>MCI (p1⁄4.005), HE>AD (p1⁄4<001); SVF: HE>MCI (p1⁄4.005), HE>AD (p1⁄4<001); PVF: HE>MCI (p1⁄4.002), HE>AD (p1⁄4.013). There were differences regarding prevalence of deficits among groups in UVF (p1⁄4.019) and SVF (p<001). AD patients showed more deficits in this VFT than the other participants. The cut-off scores of 18 and 14 points (Area under curve (AUC)1⁄4.965 and .778; sensitivity1⁄492% and 75%, specificity1⁄490% and 67%) and 42 and 27 points (AUC1⁄4.955 and .784; sensitivity1⁄487% and 70%, specificity1⁄483% and 69%) were observed as the optimal levels to detect dementia on the SVF and UVF, respectively, in relation to HE and MCI, respectively. Whereas, the cut-off scores of 21 points (AUC1⁄4.824; sensitivity1⁄472%, specificity1⁄467%) and 50 points (AUC1⁄4.816; sensitivity1⁄479%, specificity1⁄467%) were observed as the optimal level to detect MCI on the SVF and UVF, respectively, in relation to HE. Conclusions: SVF and UVF demonstrated to be efficient screening tasks to distinguish MCI and AD from HE. Conducting qualitative analyses of clusters and switches in these tasks could be able to better discriminate MCI from AD.