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P2‐246: Neural Circuitry of Grief in Dementia Caregivers
Author(s) -
Ben-Yelles Ramzi W.,
Moore Leonardo,
Iacoboni Marco,
Leuchter Andrew,
Abrams Michelle,
Ramirez-Gomez Liliana A.,
Jain Felipe
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1414
Subject(s) - grief , dementia , psychology , functional magnetic resonance imaging , depression (economics) , complicated grief , clinical psychology , psychiatry , medicine , neuroscience , disease , economics , macroeconomics
Background:Microbleeds (MB) have been shown to occur in the brains of Alzheimer’s disease (AD). We aim to elucidate frequency or distribution of MB in the typical AD and the AD patients that present atypical clinical features. Methods:We examined amnestic dominantly deficit early onset Alzheimer’s disease (EOAD)(N1⁄420), late onset Alzheimer’s disease (LOAD)(N1⁄420), and two atypical variants of l-AD (language dominantly deficit AD)(N1⁄416) and v-AD (visuospatial dominantly deficit AD)(N1⁄48) on CSF biomarkers (Ab1-42 and ptau-181) and Neuroimaging markers (C PiB-PET, F FDG-PET, Tc ECDSPECT). Among four types of AD, we analyzed the number and localization of MB, the localization and extent of PiB, CBF (cerebral blood flow) and glucose metabolism. Results: Frequency of MB was observed most frequently in l-AD (63.5%), while less number of MB in v-AD (12.5%) compared with other subtypes of EOAD (35.0%) and LOAD (35.0%). Distributions of MB in l-AD were frequently observed in left frontal and temporal lobes compared with those in right side (p<0.01, respectively). l-AD showed CBF decrease significantly in left frontal, temporal and parietal lobes compared with those in right side (p<0.001, respectively). v-AD showed decrease of CBF in bilateral occipital and parietal lobes. Conclusions: MB are thought to be related to speech dysfunctions in v-AD, also may be involved CBF decrease in left temporo-parietal and frontal lobes, which might be partly due to cerebral Ab angiopathy. The number of MB was observed relatively to relatively less degree in v-AD, which might occur different pathogenic mechanisms from l-AD.