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P2‐233: Alzheimer's Disease Risk Genes Can Predict Brain Amyloidosis
Author(s) -
Apostolova Liana G.,
Goukasian Naira,
Risacher Shan L.,
Duran Tugce,
West John D.,
Do Triet,
Grotts Jonathan,
Nho Kwangsik,
Elashoff David,
Saykin Andrew J.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1401
Subject(s) - receiver operating characteristic , regression , support vector machine , cognitive impairment , artificial intelligence , disease , medicine , computer science , statistics , mathematics
PET scans (F-florbetaben for b-amyloid and F-AV-1451 for tau pathology), conventional brain magnetic resonance imaging, and neuropsychological tests. We excluded 23 amyloid-negative MCI and AD patients and 6 amyloid-positive healthy controls. Finally, subjects consisted of four groups: 19 EO-ADS, 30 LO-ADS, 21 young controls, and 24 old controls. We compared regional FAV-1451 binding values between each ADS group and corresponding age-matched controls, and also compared between EO-ADS and LO-ADS groups. Results:Compared to each age-matched control group, both ADS groups showed markedly increased F-AV1451 binding throughout the entire cortical region. However, the binding was significantly increased in the sensorimotor cortex only in the EO-ADS patients. Compared to the LO-ADS patients, the EO-ADS patients showed greater F-AV-1451 binding in the sensorimotor, and superior and inferior parietal cortices. In EOADS, F-AV-1451 binding in the prefrontal, superior and inferior parietal, occipital, lateral temporal, precuneus, and posterior cingulate regions negatively correlated with the performances of attention, visuospatial, and frontal executive function tests. Performance on a memory test was negatively correlated with the F-AV-1451 binding in the hippocampus and entorhinal cortex. In contrast, we could not find any correlation between F-AV1451 binding and cognition in LO-ADS patients with partial volume uncorrected values. However, after correcting for partial volume effect, LO-ADS patients showed negative correlation between their performance on a memory test and the medial temporal F-AV-1451 binding. Conclusions: Our findings suggest that EO-ADS patients have a greater tau burden than LO-ADS patients, particularly in the sensorimotor and the parietal cortices. Different topographical distribution patterns of tau may affect various types of cognitive impairment in EO-ADS patients.