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P2‐225: Dopaminergic Depletion in Anterior Caudate and Putamen Causes Cognitive Impairment in Parkinson's Disease
Author(s) -
Ye Byoung Seok,
Lee Jae Jung,
Lee Yoonju,
Lee Phil Hyu,
Sohn Young H.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1393
Subject(s) - putamen , dopaminergic , striatum , psychology , neuropsychology , caudate nucleus , parkinson's disease , dopamine transporter , executive dysfunction , cognition , neuroscience , dopamine , cognitive deficit , medicine , disease , cognitive impairment
Background: Exact relationship between regional dopaminergic depletion in the striatum and cognitive dysfunction has not been elucidated in Parkinson’s disease (PD). We investigated the relationship between regional dopamine transporter (DAT) uptake and cognitive dysfunction in patients with PD. Methods:One hundred and forty-six patients with PD underwent DAT scan and detailed neuropsychological tests. Regional DAT uptake was investigated in the ventral striatum, anterior and posterior caudate, and anterior, posterior, and ventral putamen using mean occipital uptake as a reference. Domain-specific cognitive z scores were calculated for attention, memory, visuospatial, and frontal/executive function. The effects of each regional DAT uptake on cognition were evaluated using general linear models for cognitive scores using age, gender, education, and Beck Depression Inventory as covariates. Results: After Bonferroni’s correction for multiple comparisons, DAT uptake in the anterior caudate and anterior putamen were associated with cognitive scores in attention and frontal/ executive domains. Memory and visuospatial z-scores did not correlate with regional striatal DATuptake.Conclusions: Our results demonstrate that striatal dopamine depletion in the anterior caudate and anterior putamen contribute to the cognitive dysfunction in PD patients. Dopamine depletion was associated with attention and frontal/executive dysfunction, but not with memory and visuospatial dysfunction.