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P2‐199: Neuropsychological Tests and Mild Cognitive Impairment Subtypes Associated with Development of Dementia in Non‐Demented Patients with Parkinson's Disease
Author(s) -
Kim Jae Woo,
Lee Su Yun
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1366
Subject(s) - dementia , neuropsychology , parkinson's disease , cohort , psychology , disease , cognition , medicine , audiology , pediatrics , psychiatry
primary progressive aphasia had their clinical and imaging data retrospectively analysed. Only monolingual Chinese subjects fulfilling international consensus criteria for svPPA were included. Ten ageand gender-matched healthy controls (HC) and ten Alzheimer’s disease (AD) subjects were included for comparison. Results: Five svPPA patients were recruited (mean age 6564.2 years, 20% male). Compared with AD, svPPA subjects were better educated (mean education 12.261.8 vs 5.363.0 years), but had lower mean baseline MMSE scores (17.069.6 vs 21.563.4). Volumetric comparisons of grey matter regions revealed asymmetrical (left > right) atrophy in the anterior temporal, limbic (insular and anterior cingulate) and occipitoparietal cortices in svPPA compared with AD. Compared with HC, svPPA subjects showed predominantly left-sided dorsolateral prefrontal, anterior temporal and limbic (insular and anterior cingulate) atrophy, including greater atrophy in left > right occipitoparietal and thalamic regions. Conclusions: The left anterior temporal lobe remains a hub for semantic processing in the Chinese language. Greater involvement of posterior cortical regions in a lateralized manner (left>right) suggests additional contribution of these regions typically involved in visual processing to language processes unique to the Chinese logographic system.