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IC‐P‐106: Cross‐Sectional Modeling of Regional Perfusion and Gray Matter Volume in Alzheimer's Disease
Author(s) -
Bron Esther E.,
Young Alexandra L.,
Oxtoby Neil P.,
Smits Marion,
Swieten John C.,
Wink Alle Meije,
van der Flier Wiesje M.,
Barkhof Frederik,
Golay Xavier,
Niessen Wiro J.,
Klein Stefan,
Alexander Daniel C.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.136
Subject(s) - parahippocampal gyrus , temporal lobe , medicine , cerebral blood flow , fusiform gyrus , magnetic resonance imaging , cardiology , nuclear medicine , radiology , functional magnetic resonance imaging , psychiatry , epilepsy
yloid loadings and FDG, particularly in the angular gyrus and posterior cingulate cortex (Figure 2A). For comparison, no significant regions were observed using a whole cortex average of b-amyloid burden (Figure 2B). Conclusions:Multivariate, cross-correlation analyses can uncover complex brain patterns not found with univariate statistical analysis approaches. These results support the notion that it is the spatially distributed, rather than focal, accumulation of b-amyloid that is associated with metabolic dysfunction. Future work will expand this analysis to identify the pattern of b-amyloid maximally related to metabolic connectivity.