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P2‐179: The Differential Roles of Apathy and Depression as Predictors for Conversion from Mild Cognitive Impairment to Dementia
Author(s) -
Hwang Tzung-Jeng,
Chiang Chih-Lin,
Chiu Ming-Jang,
Chen Ta-Fu,
Yip Ping-Keung
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1346
Subject(s) - apathy , depression (economics) , dementia , confidence interval , odds ratio , medicine , psychiatry , psychology , cognition , disease , economics , macroeconomics
marginally significant increase of risk for participants who were PiB+ and had agitation (3.70 [0.87, 15.7]). We also observed a dose-response pattern: Being PiB+ and having one NPS increased the risk of incident MCI by more than two folds (2.68 [1.47, 4.89]), being PiB+ and having two or more NPS increased the risk by more than three times (3.57 [1.63, 7.81]), and being PiB+ and having three or more NPS increased the risk by more than six times (6.33 [2.19, 18.3]). Conclusions:Cortical amyloid deposition and depression synergistically interact in further elevating the risk of incident MCI. Similar patterns were observed for apathy, appetite changes, nighttime behavior and agitation. Research investigating presymptomatic AD biomarkers may need to account for NPS in both observational studies as well as clinical trials.