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IC‐P‐103: Active and Passive Reserve Differentially Mitigate Cognitive Symptoms in Demented and Non‐Demented Stages of Alzheimer’s Disease
Author(s) -
Groot Colin,
Loenhoud Anita C.,
Berckel Bart N.M.,
Barkhof Frederik,
Koene Teddy,
Teunissen Charlotte E.,
Scheltens Philip,
van der Flier Wiesje M.,
Ossenkoppele Rik
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.133
Subject(s) - cognitive reserve , dementia , psychology , neuropsychology , verbal fluency test , boston naming test , cognition , atrophy , alzheimer's disease , neuropathology , audiology , medicine , neuroscience , disease
most strongly associated with the WCSS (Spearman r1⁄4-0.345, p1⁄40.027), but it was not associated with total WMH volume (r1⁄40.147, p1⁄40.358). This was confirmed in the NACC cohort (r1⁄4-0.247, p1⁄40.031 versus r1⁄4-0.03, p1⁄40.789). Conclusions: The WCSS (i) is independent of the total volume of WMHs, as the WCSS of an arbitrary number of spherical WMHs vanishes, (ii) is rater-independent, as it is computed fully automatically, and (iii) seems to be more strongly associated with cognitive performance in specific domains than the total WMH volume.