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IC‐P‐100: Verbal Associative Binding is Associated with Amyloid‐Beta Deposition in Self‐Referred Subjective Memory Complainers But Not In Cognitively Normal Volunteers
Author(s) -
Snitz Beth E.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.129
Subject(s) - prodrome , psychology , cognition , neuropsychology , episodic memory , neuroimaging , semantic memory , association (psychology) , audiology , verbal learning , verbal memory , clinical psychology , psychiatry , medicine , psychosis , psychotherapist
6CSF Ab1-42*6[ F]FDG + Sex. The analysis was perform using VoxelStats, which performs statistical analysis at each voxel. Results:Our model revealed that regional hypometabolism in prefrontal cortex, cingulate cortex, entorhinal cortex, and thalams with the decline in CSF Ab1-42 has a significant synergistic impact in decline in cognition in Tg (Figure 1).Conclusions:Our results revealed that a decrease in metabolism in prefrontal, cingulate, entorhinal cortex, and thalamus, with an increase brain Ab load as represented as decline in CSF Ab1-42, leads to a decline in cognition.