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P2‐043: Galantamine Nanoparticles Improved The Efficacy of Mesenchymal Stem Cells When Given in Combination in an Animal Model of Alzheimer's Disease
Author(s) -
Misra Shubham,
Chopra Kanwaljit,
Medhi Bikash
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1247
Subject(s) - mesenchymal stem cell , oxidative stress , inflammation , medicine , pharmacology , neurogenesis , population , immunology , endocrinology , pathology , biology , microbiology and biotechnology , environmental health
ity Optimized Dynamics Algorithm New (FRODAN) was used to determine representative structures. Results:Novel methods to measure tau conformational changes and aggregation demonstrated the effect of small molecule oligomerization inhibitors. There is a correlation between the activity of the inhibitors in an in vitro oligomerization assay and the measured changes in tau conformation. Conclusions: By utilizing electrochemical and mass spectrometry techniques, we have demonstrated small molecule dependent changes in tau conformation. This information will be used for optimization of small molecule inhibitors against tau misfolding and aggregation.