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P2‐027: Systematic Review of RCTS of Interventions for Vascular Cognitive Impairment
Author(s) -
Cieslak Alicja,
Barber Philip,
Black Sandra E.,
Chen Jerry,
Edwards Jodi D.,
Elbayoumi Heba,
Frayne Richard,
Field Thalia S.,
Hachinski Vladimir,
Hegedus Janka,
Hanganu Victoria,
Ismail Zahinoor,
Kanji Jamila,
Nakajima Makoto,
Noor Raza,
Peca Stefano,
Sposato Luciano,
Swartz Richard H.,
Zerna Charlotte,
Smith Eric E.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1231
Subject(s) - dementia , randomized controlled trial , vascular dementia , medicine , cochrane library , placebo , psychological intervention , memantine , disease , psychiatry , physical therapy , pathology , alternative medicine
were dose proportional across the tested doses. SUVN-G3031 has achieved the projected efficacy concentrations and attained steady state on day 7 upon multiple administrations in healthy male subjects. SUVN-G3031 is well tolerated in humans with adequate plasma exposure for efficacy and favorable pharmacokinetics suitable for once a day oral administration. Phase II enabling long term safety studies for SUVN-G3031 is currently ongoing. The Phase II study is being planned.