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P2‐026: SUVN‐G3031, a Potent and Selective H3 Receptor Inverse Agonist: Safety, Tolerability and Pharmacokinetics in Humans
Author(s) -
Bhyrapuneni Gopinadh,
Mudigonda Koteshwara,
Penta Kiran Kumar,
Chowdary Palacharla Veera Raghava,
MuddageswaraRao,
Jayarajan Pradeep,
Abraham Renny,
Subramanian Ramkumar,
Goyal Vinod Kumar,
Pandey Santosh Kumar,
Boggavarapu Rajesh Kumar,
Shinde Anil K.,
Nirogi Ramakrishna
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1230
Subject(s) - tolerability , pharmacokinetics , cmax , adverse effect , medicine , pharmacology , agonist , safety pharmacology , adme , receptor , drug
Background:Several types of MT have approved benefits in AD via rehabilitation and psychiatric care. However, there are few studies of MT on neurophysiological function using event-related potentials (ERP). Methods:We consecutively recruited mild AD cases (Clinical dementia rating1⁄4 0.5w1), who voluntarily separated into MT group or control group (CG) for 3 months course. These assessments of clinical MTeffect were including Mini-mental state examination (MMSE), Cognitive abilities screening instrument (CASI) in both groups, and ERP only in MT group. The intervention mode of MT was using the medical resonance therapy music (RRR 128 for concentration/memory and RRR 931 for relaxation), separately listening by headphone for 30 minutes in the daily morning and before sleep respectively. Results:There were 23 and 20 cases in MT and CG group respectively. The baseline ERP N200 (N2) and P300 (P3) responses of MT were poor (eg. Mean CzN21⁄4290.1637.81 ms and CzP31⁄4445.2671.29 ms). After comparing the two groups data, we found the differences of MMSE & CASI after 3 months in MT (0.463.49 & -2.567.53) were better than CG (-2.465.51 & -5.8618.12). But they were not statistically significant (p1⁄40.051 & 0.458). Further adjusting by gender, age, education level and corresponding baselinemeasures in analysis of covariance, we found adjusted differences of MMSE and CASI in MTwere slightly better than those in CG, yet without statistical significance. In the assessments of ERP in MT, the 3 months differences of P3 amplitude in Fz and Cz sites were significantly increasing (5.266.87 mV and 2.463.31 mV, p1⁄40.030 and 0.024). The 3 months differences of all N2 components, P3 latency, accurate response rate and mean responsive time were improving, yet not reaching statistical significance. Conclusions: The AD patients had poor cognitive process, even in very early and mild stage. The three-monthmedical resonance therapymusic shows significant effect on responsive intensity of information processing in mild AD patients. No apparently additional benefits of this MTwere noted in the globally cognitive assessments for 3 months.