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IC‐P‐094: Association Between N‐Back Working Memory Activation on FMRI and Cognitive Assessment of Executive Function
Author(s) -
West John D.,
Risacher Shan L.,
Gandhi Pratik K.,
Wu Yu-Chien,
Tallman Eileen F.,
McDonald Brenna C.,
Apostolova Liana G.,
Farlow Martin R.,
Brosch Jared R.,
O'Neill Darren P.,
Gao Sujuan,
Brown Steven A.,
Glazier Bradley S.,
Unverzagt Frederick W.,
Saykin Andy J.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.123
Subject(s) - working memory , functional magnetic resonance imaging , cognition , psychology , neuropsychology , default mode network , executive functions , association (psychology) , neuroimaging , cognitive decline , audiology , posterior cingulate , n back , neuroscience , medicine , dementia , disease , psychotherapist
right hippocampi (r1⁄4-0.66,p<0.002; r1⁄4-0.68,p<0.002 respectively) as well as the left and right thalami (r1⁄4-0.66,p<0.002; r1⁄4-0.68,p<0.002 respectively). A weaker but similar relationship was observed in the control group, possibly due to a smaller population size (see Table 1). Figures 1.a,c show correlation coefficients overlaid on ICBM template for ventricular regions for the ex-CFL and control groups. Figure 1.b shows the significant FDR corrected p-value map for the ex-CFL cohort. Figures 2.a-c show similar images for subcortical regions. The color-coded bars in Figures 1.a-c and 2.a-c represent correlation coefficients values: warm colors correspond to regions of enlargement with age i.e. ventricles; cold colors correspond to areas negatively correlated with age i.e. hippocampi and thalami. Figure 2.b shows the significant regions after FDR correction in the ex-CFL. Table 1 shows correlation coefficients and FDR corrected p-values for the two groups for areas indicated by arrows. The uncorrected p-values for the control group did not survive FDR correction. Conclusions: Our results revealed extensive changes associated with age in the ex-CFL population. The changes predominantly involved volume decreases in the hippocampi and thalami, and volume increases in the ventricles. DBM may be a sensitive measure for detecting focal brain atrophy in patients that have suffered multiple concussions. IC-P-094 ASSOCIATION BETWEEN N-BACK WORKING MEMORYACTIVATION ON FMRI AND COGNITIVE ASSESSMENT OF EXECUTIVE FUNCTION John D. West, Shannon L. Risacher, Pratik K. Gandhi, YuChien Wu, Eileen F. Tallman, Brenna C. McDonald, Liana G. Apostolova, Martin R. Farlow, Jared R. Brosch, Darren P. O’Neill, Sujuan Gao, Steven A. Brown, Bradley S. Glazier, Frederick W. Unverzagt, Andy J. Saykin, 1 Indiana University School of Medicine, Indianapolis, IN, USA; 2 Indiana Alzheimer Disease Center, Indianapolis, IN, USA. Contact e-mail: jdwest@ iupui.edu