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IC‐P‐093: Deformation Based Morphometry Study of Retired CFL Football Players
Author(s) -
Dadar Mahsa,
Misquitta Karen,
Tarazi Apameh,
Ebraheem Ahmed,
Multani Namita,
Khodadadi Mozhgan,
Goswami Ruma,
Wennberg Richard,
Tator Charles,
Green Robin,
Colella Brenda,
Davis Karen,
Mikulis David,
Collins Louis,
Tartaglia Maria Carmela
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.122
Subject(s) - cohort , football , population , nuclear medicine , american football , magnetic resonance imaging , medicine , psychology , cartography , radiology , geography , environmental health , archaeology
study examined cerebral blood flow (CBF) as a potential biomarker of changes in brain physiology in participants at risk for progression to AD based on SCD or MCI. Methods: 51 participants were included from the Indiana Alzheimer Disease Center, including 27 cognitively normal older adults (CN), 18 participants with SCD, and 7 participants with MCI. The total score from the first 12 items of the Cognitive Change Index (CCI)-Self was used to define SCD. CBF maps were obtained by processing 3D pCASL images using a 3D GRASE sequence in a 3T Siemens Prisma Scanner [1]. CBF maps were smoothed and normalized. Group comparisons were performed using an ANCOVAmodel in SPM8, covaried for age and gender. Results:The SCD group showed elevated CBF relative to MCI in left posterior cingulate and relative to MCI and CN in left superior temporal gyrus, right parahippocampal gyrus, and right medial occipital gyrus (Figure 1). Further, MCI showed a trend for reduced CBF in these regions relative to CN. Within the SCD group, CBF in these areas showed a significant negative association with the MoCA total score. Across all groups, the left posterior cingulate CBF measure showed a positive association with delayedmemory on the Rey Verbal Learning Test and negative association with the CCI-Informant total score. Conclusions: SCD participants show increased resting CBF in comparison to CN and MCI groups, which may indicate an early compensatory physiological response. The negative correlation of CBF and MoCA scores within the SCD group supports this hypothesis. However, across all groups, greater CBF appears related to better cognition. Replication and longitudinal follow-up are needed to clarify these initial findings and further evaluate CBF as a biomarker in those at risk for AD. [1] Jann, et al. (2015) NeuroImage.