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IC‐P‐088: Cognitive Decline is Driven By The Regional Synergism Between Amyloid Load and Hypometabolism in Mild Cognitive Impairment
Author(s) -
Pascoal Tharick A.,
Mathotaarachchi Sulantha S.,
Benedet Andrea Lessa,
Shin Monica,
Kang Min Su,
Mohades Sara,
Beaudry Thomas,
Soucy Jean-Paul,
Gauthier Serge,
Rosa-Neto Pedro
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.117
Subject(s) - statistical parametric mapping , voxel , standardized uptake value , positron emission tomography , cognitive decline , cognitive impairment , medicine , cognition , psychology , abnormality , receiver operating characteristic , nuclear medicine , disease , dementia , neuroscience , psychiatry , radiology , magnetic resonance imaging
decline than Ab+ ε4 non-carriers on both the EM (d1⁄40.41) and EF (d1⁄40.24) composites. Ab+ ε4 non-carriers did not show greater rates of hippocampal atrophy or Ab accumulation when compared to Abε4 non-carriers. However, when compared to Ab+ ε4 non-carriers, Ab+ ε4 carriers showed significantly greater rates of hippocampal atrophy (d1⁄40.56) and Ab accumulation (d1⁄40.28). Conclusions:The results show that in older adults with MCI, Ab+ and ε4 interact to increase the rate of cognitive decline, hippocampal volume loss and Ab accumulation. Significant decline in cognitive function is also evident in Ab+ ε4 non-carriers, although this is slower than that for Ab+ ε4 carriers. These results suggest that Ab and ε4 have a synergistic influence on the AD trajectory and are important considerations for clinical trials.