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P1‐410: Lifetime Recreational Physical Activity is Associated with CSF Amyloid in Cognitively Asymptomatic Adults
Author(s) -
Torres Elisa R.,
Merluzzi Andrew P.,
Zetterberg Henrik,
Blennow Kaj,
Carlsson Cynthia M.,
Okonkwo Ozioma C.,
Asthana Sanjay,
Johnson Sterling C.,
Bendlin Barbara B.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1162
Subject(s) - asymptomatic , physical activity , medicine , cerebrospinal fluid , psychology , gerontology , physical therapy
studies addressing the relationship between coronary artery calcium score (CACS) and brain structures. Considering CACS is a useful marker in early detection of subclinical atherosclerosis, it would be important to investigate the effects of CACS on brain structure changes in cognitively normal individuals to prevent cognitive decline and dementia. We therefore investigated the association of CACS with cerebrovascular diseases measured by white matter hyperintensities (WMH) and neurodegeneration measured by cortical thickness in a large sized cohort of cognitively normal individuals. Methods: A total of 512 participants in a health screening program were enrolled. Multi-detector computed tomography was performed to determine CACS. Cortical thickness was measured using a surface-based method. Linear mixed models were used to assess the association between CACS and cortical thickness. Results: Multivariable models adjusted for covariates showed that higher CACS was significantly correlated with decreased global mean cortical thickness (P-value 1⁄4 0.047). In particular, higher CACS with cortical thinning had regional specificity in the bilateral dorsolateral prefrontal, precuneus, superior parietal, and left medial prefrontal regions, which generally overlapped with the distribution of default mode network (DMN). However, there was no significant association between CACS and WMH (P value 1⁄40.980). Conclusions: Our findings show that CACS might affect cortical thinning, especially in DMN, rather than cerebrovascular burdens in cognitively normal individuals, suggesting that CACS may be an important modifiable risk factor in the development or progression of Alzheimer’s disease.