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P1‐404: APOE Genotype Modifies The Effects of Aerobic Training on Brain Glucose Metabolism in Subjects with Mild Cognitive Impairment
Author(s) -
Porto Fabio H.G.,
Coutinho Artur M.N.,
Duran Fabio L.S.,
Ono Carla R.,
Pinto Ana L.S.,
Gualano Bruno,
Gomes Helio R.,
Talib Leda Leme,
Forlenza Orestes Vicente,
Buchpiguel Carlos A.,
Nitrini Ricardo,
Brucki Sonia M.D.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1156
Subject(s) - precuneus , voxel , positron emission tomography , medicine , apolipoprotein e , gyrus , middle temporal gyrus , superior frontal gyrus , middle frontal gyrus , posterior cingulate , psychology , audiology , neuroscience , cognition , nuclear medicine , radiology , disease
proceeded in these center. This research was the analysis of the results of mass screening in Seongdong-gu center for dementia. Methods: From July 2007 to December 2013, we registered 23,186 persons at Seongdong-gu center for dementia and all individuals were aged 60 and older. They classified the subjects into cognitive impairment group and normal group by Korean version Mini-Mental State Examination (K-MMSE). Next, the cognitive impairment group was assorted by Consortium to Establish a Registry for Alzheimer’s Disease Korean version (CERAD-K) and the examination of two neurologists. We investigated the prevalence of dementia and the usefulness mass screening of dementia among that data. Results:A total of 23,186 subjects were enrolled, of which 3,286 were cognitive impairment group, and 1,856 were diagnosed with dementia finally. The mean age was 77.1 years, 67% were female and the mean education level was 6.3 years. Disease incidence of dementia was lower year by year, but this went up when we focused the group who has high risk of dementia. Especially, the sharp decline was observed in complete enumeration dementia screening test about the specific age group. Conclusions:These results could suggest that we should focus on the group who has high risk of dementia in screening for dementia and it requires a more judicious approach.