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P1‐400: The Comparisons of Etiologies, Clinical Features Focusing on Behavior Problem and Caregiver Burdens Between Early Onset Dementia (Eod) and Late Onset Dementia (LOD)
Author(s) -
Kwon Jay Cheol,
Kim Byunggun,
Lee Kyungsoo,
Choi Nack-cheon,
Jung Yohan
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1152
Subject(s) - dementia , delusion , etiology , medicine , disease , cognition , psychiatry , caregiver burden , pediatrics , clinical psychology , audiology
and n1⁄4546 were MCI. ROC curve analysis revealed 8 items of the IQCODE most sensitive in discriminating MCI. Low sensitivity was observed in the discriminant indices of the P-AD8 (Area under the curve (AUC): 0.60, sensitivity: 54.4%, specificity: 65.1%, cutoff: 1), I-AD8 (AUC: 0.58, sensitivity: 45.6%, specificity: 70.8%, cut-off: 1), 16-item IQCODE (AUC: 0.56, sensitivity: 57.5%, specificity: 54.5%, cut-off: 3.03) and the 8-item IQCODE (AUC: 0.58, sensitivity: 55.5%, specificity: 56.9%, cut-off: 3.06). However, the sensitivities of the P-AD8, 16-item and 8item IQCODE were higher than the I-AD8 (p<0.001). Therefore, combination of the P-AD8 and 16-item IQCODE (AUC: 0.60, sensitivity: 79.1%, specificity: 38.8%) or 8-item IQCODE (AUC: 0.59, sensitivity: 78.1%, specificity: 39.2%) demonstrated increase in overall sensitivity. Though there were significant differences between the sensitivities of the two combinations (p1⁄40.030), comparison of AUC’s showed no differences (p1⁄40.899). Conclusions:The compensatory combination of the P-AD8 with the 8-item IQCODE improves overall sensitivity for detecting MCI. The absence of significant functional decline in the MCI criteria accounts for the poor AUC of each test. This indicates that tests designed to detect functional decline are not suitable to detect MCI.