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P1‐396: Simple Test of Manual Dexterity Can Identify Persons at High Risk for Neurodegenerative Diseases in The Community
Author(s) -
Darweesh Sirwan,
Wolters Frank J.,
Hofman Albert,
Stricker Bruno,
Koudstaal Peter J.,
Ikram M. Arfan
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1148
Subject(s) - parkinsonism , dementia , medicine , rotterdam study , hazard ratio , disease , cohort , population , confidence interval , psychiatry , pediatrics , physical therapy , environmental health
(95%CI: 7.0-10.0) per 100 person-years. Individuals with amnestic MCI multiple domains were the most risky ones for dementia, with the conversion rate of 14.3 (95%CI: 10.3-18.3) per 100 personyears. Older age (HR1⁄41.09, 95%CI: 1.05-1.14), apolipoprotein E -ε4 positive (HR1⁄42.15, 95%CI: 1.21-3.81), and low Mini-Mental State Examination score (HR1⁄41.18, 95%CI: 1.06-1.28) at baseline were independent risk predictors for the conversion from MCI to dementia. Conclusions: Our findings suggest that 6% of Chinese elderly with MCI progress to dementia annually. Further prospective studies in China are urgently needed to examine risk and protective predictors in order to seek the proper interventions for cognitive decline in the increasing aging population.