P1‐394: Prevalence and Characteristics of Patients with Alzheimer’s Disease Eligible for a Disease Modifying Drug (Panacea)

and 2012 using a list of six yes/no questions about changes in cognitive function. The average of the 2008 and 2012 answers was used to classify SCD as “good” (54% of men), “moderate” (38%) or “poor” (7.5%). We adjusted for age, profession, smoking, body mass index, adherence to the Alternative Healthy Eating Index as a measure of a healthy diet, diabetes, asthma, hypercholesterolemia, hypertension, cancer, and cardiovascular disease. Adjustments were also made for depression, emphysema, physical impairment, and poor balance. Results:Men in the highest quintile of mid-tolate life physical activity had a 37% lower odds of poor vs good SCD score than those in the lowest quintile (multivariable-adjusted odds ratio (OR) 0.63; 95% CI 0.54-0.75; P for trend <0.0001). Among men who had never participated in strenuous physical activity in early adulthood (n1⁄43250, 11%), those who reported the highest tertile of physical activity during mid-to-late life had a 45% lower odds of poor SCD score compared with those in the lowest tertile (multivariable-adjusted OR 0.55; 0.63-0.92). Similarly, the odds of poor SCD score were lower among men who participated in strenuous physical activity in college than among those who did not; this inverse association remained after adjusting for mid-to-late life physical activity (OR 0.78; 95% CI 0.67-0.94). Conclusions: Being physically active during early adulthood and mid-to-late life are independently associated with lower odds of late-life SCD.