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P1‐390: Lower Gait Speed is Independently Associated with Increased Mortality Risk Among People with Dementia in Low‐ and Middle‐Income Countries: Results from The 10/66 Dementia Research Group Population‐Based Cohort Study
Author(s) -
Piovezan Ronaldo D.,
Acosta Daysi,
Guerra Mariella,
Huang Y.,
Rodriguez Juan J. Llibre,
Salas Aquiles,
Sosa-Ortiz Ana Luisa,
Jimenez-Velazquez Ivonne Z.,
Prince Martin J.,
Ferri Cleusa
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1142
Subject(s) - dementia , quartile , medicine , confounding , preferred walking speed , gait , population , proportional hazards model , demography , gerontology , physical medicine and rehabilitation , confidence interval , environmental health , disease , sociology
mance was investigated in stable and declined participants. Methods: Participants (n1⁄4123, 70.366.0 years, 61% men, out of the Heinz Nixdorf Recall study) performed neuropsychological andMR-tomographic tests twicewithin 2.560.2 years. Participants were classified as “cognitively healthy”, “mildly cognitively impaired” (MCI) or “demented” at both time points. Participants who did not change over time were classified as “stable”, those who changed from “cognitively healthy” to “MCI” or from “MCI” to “demented” were classified as “declined”. Annualized percentage volume changes of HC, TL, and the whole brain were determined by atlas-based MRI volumetry, an investigator-independent method using SPM algorithms. All volumetric data were adjusted for intracranial volume. Group comparisons were performed using covariance analysis adjusted for age, gender and education. The association of percentage volume changes and change in cognitive performance were examined using linear regression models adjusted for age, gender and education in both groups. Results: Cognitively declined participants showed more volume loss in the HC (stable: 0.12% 6 1.82 SD; declined: -2.31% 6 1.87 SD), TL (stable: -0.75% 6 0.90 SD; declined: -1.75% 6 0.93 SD) and in the whole brain (stable: -0.78% 6 0.74 SD; declined: -1.40% 6 0.76 SD). Furthermore, change in cognitive performance was strongly associated with change in hippocampal volume in the declined group (R1⁄4 42.6%, b1⁄4 0.659, B1⁄42.487; 95% confidence interval (0.77;4.20), p1⁄40.008) but not in the stable group (R1⁄4 1.8%, b1⁄4 -0.093, B1⁄4-0.142; 95% confidence interval (-0.44;-0.16), p1⁄40.35). Conclusions:This study shows that volume changes of HC, TL and the whole brain are potential biomarkers for cognitive deficits. Our results support previous studies regarding the predictive value of HC volume for cognitive performance in a population-based setting.