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P1‐387: Incidence of Dementia Subtypes in a Community‐Based Prospective Cohort Study: The Adult Changes in Thought (ACT) Study
Author(s) -
Crane Paul K.,
Gross Alden L.,
Gibbons Laura E.,
Mez Jesse,
Trittschuh Emily,
Mukherjee Shubhabrata,
Saykin Andy J.,
McCurry Susan M.,
McCormick Wayne,
Bowen James D.,
Kukull Walter A.,
Larson Eric B.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1139
Subject(s) - dementia , cohort , neuropsychology , medicine , incidence (geometry) , cognition , etiology , cohort study , disease , prospective cohort study , psychology , gerontology , psychiatry , pediatrics , clinical psychology , physics , optics
matory processes. Previously, a Dietary Inflammatory Index (DII) was associated with inflammatory biomarkers in the Women’s Health Initiative (WHI). Our objective was to evaluate the association of an anti-inflammatory diet, indicated by lower DII scores, with incident MCI/dementia in theWHIMemory Study (WHIMS). Methods:DII scores characterize diet on a continuum from minimally inflammatory (low score) to maximally inflammatory (high score). We used baseline food frequency questionnaire data from n 1⁄4 7,109 WHIMS participants (aged 64 to 80 years) to calculate DII scores which were then partitioned into quintiles. Cox models were used to evaluate risk of MCI/dementia onset across DII quintiles, adjusted for age, race, education, hormone therapy treatment, non-steroidal anti-inflammatory use, diabetes, hypertension, caloric intake, physical activity, and body mass index using the highest DII quintile (Q5) as the referent. MCI/dementia status was adjudicated centrally according to Peterson’s MCI criteria and DSM-IV criteria for probable dementia using longitudinal neurocognitive test data, informant Dementia Questionnaires, and health history data. Results:Over an average of 9.7 years (standard deviation: 5.4), there were 1,081 incident MCI/dementia cases. Diets that were less inflammatory were associated with later MCI/dementia onset. Hazard ratios (HR) comparing lower, less inflammatory DII quintiles to the highest quintile referent (Q5: pro-inflammatory) were: Q4-HR: 0.77, 95% Confidence Interval (CI) 0.64-0.94; Q3-HR: 0.82, 95% CI 0.67-0.99; and Q2-HR: 0.75, 95%CI 0.62-0.92. The lowest DII quintile (Q1) tended toward a reduced, although not statistically significant risk association for MCI/dementia (Q1-HR: 0.87, 95% CI 0.71-1.06) compared to the highest quintile (Q5). Conclusions: Anti-inflammatory diets were associated with a lower risk of MCI/dementia. While evidence for the protective effects of healthy diets has been widely publicized, this is one of few studies to show that an anti-inflammatory diet is associated with a reduced risk for MCI/dementia.